He was posted as Secretary, Public Service Department in the Office of the Secretary to the Federal Military Government and Head of Service (January 12, 1984- January 31, 1985), responsible for the Management of the Administrative Cadre of the Civil Service and Senior Management Staff of Professional Cadres of the Service. He was the Director, External Finance, Ministry of Finance (an alternate Governor for Nigeria on the Board of African Development Bank) (February 4, 1985- January, 1986). He was the Permanent Secretary, Federal Ministry of Industries (January 1986-February 1987), Permanent Secretary, Federal Ministry of Works and Housing (February – May 1988), Director-General, the Directorate of Foods, Roads and Rural Infrastructure (DFFRI) (June 1988- March 1989), Director General, Federal Ministry of Social Development, Youth and Sports (March 1989- March 1990), Director General, Planning, Federal Ministry of Budget and Planning (January – September 1990).
Chief Ufot Ekaette was appointed the deputy governor of Akwa Ibom state, vice Chairman State Executive Council and State Security Council; Chairman, Finance and General Purposes Committee and State boundaries committee. He also had statutory responsibilities for Local Government Affairs (September 1990- January 1992).
He was the Chairman Corporate Affairs Commission, Abuja (July 1992- August 1994) and member of the Assets and Liabilities Sharing Committee, Plateau/Nasarrawa; and Enugu/Abia/Ebonyi States (October 1996-February 1997).
He retired from the Federal Civil Service in February 1994 after 30yeras of distinguished career and engaged in private business thereafter. He was a non-executive Director of First Bank of Nigeria PLC (March, 1996-May 1999). He was appointed Secretary to the Government of the Federation by President Olusegun Obasanjo, GCFR, and served between May 1999 and May 2007.